2. Signaling Pathways
  3. Apoptosis
    Metabolic Enzyme/Protease
  4. Glutathione Peroxidase

Glutathione Peroxidase

Glutathione Peroxidase

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Glutathione peroxidases (GPx) are a family of enzymes with the ability to reduce organic and inorganic hydroperoxides to the corresponding alcohols using glutathione or thioredoxin as an electron donor. These enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative damage. Dysregulated GPx expression is connected with severe pathologies, including obesity and diabetes. GPx1 has been reported to be involved in both pro- and anticancer effects in different tumor models.

In mammals, the GPxs family consists of eight members (GPx1-GPx8) identified so far; five of them (GPx1-GPx4 and GPx6) contain selenocysteine in the catalytic center and the other three are cysteine-containing proteins. GPx1 is one of the most critical members of the GPxs family that catalytically reduces hydrogen peroxide to produce water. The function of GPx3 is to scavenge H2O2 and lipoperoxides in the plasma to reduce systematic oxidative stress and to maintain the bioavailability of vascular nitric oxide. Gpx4 is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called ferroptosis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W127709
    Chlorophyll b
    Chlorophyll b is an orally active tetrapyrrole derivative and pigment. Chlorophyll b can be obtained from photosynthetic organisms such as plants and algae. Chlorophyll b acts as a hydrogen donor and increases Glutathione levels. Chlorophyll b has antioxidant activity and functionally replaces chlorophyll a in photosystem II to participate in photosynthesis. Chlorophyll b reduces Cisplatin (HY-17394)-induced DNA damage, chromosome instability, and oxidative stress. Chlorophyll b is mainly used in the study of plant photosynthesis mechanism.
    Chlorophyll b
  • HY-139915
    MPO-IN-1
    		Inhibitor 99.02%
    MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase (MPO). MPO-IN-1 has IC50s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation.
    MPO-IN-1
  • HY-139001
    JKE-1716
    		Inhibitor 98.04%
    JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition.
    JKE-1716
  • HY-N11552
    Sorbifolin
    		Inhibitor 99.58%
    Sorbifolin, a flavone glucoside, can be isolated from the Pterogyne nitens. Sorbifolin has myeloperoxidase inhibitory and radical scavenging activities. Sorbifolin is also a MPO inhibitor with an IC50 value of 19.2 nM.
    Sorbifolin
  • HY-151212
    BCP-T.A
    		≥99.0%
    BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    BCP-T.A
  • HY-157762
    GPX4-IN-9
    		Inhibitor 98.03%
    GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research.
    GPX4-IN-9
  • HY-163332
    MPO-IN-6
    		Inhibitor
    MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC50s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent.
    MPO-IN-6
  • HY-168011
    GPX4-IN-14
    		Inhibitor
    GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects.
    GPX4-IN-14
  • HY-163272
    GPX4/CDK-IN-1
    		Inhibitor
    GPX4/CDK-IN-1 (Compound B9) is a dual inhibitor of GPX4 and CDK, with IC50 values of 542.5 nM, 191.2 nM and 68.1 nM for GPX4, CDK4 and CDK6, reapectively. GPX4/CDK-IN-1 shows strong cancer cell growth inhibition in vivo.
    GPX4/CDK-IN-1
  • HY-149455
    GPX4-IN-8
    		Inhibitor
    GPX4-IN-8 (compound A80) is a potent GPX4 inhibitor. GPX4-IN-8 shows antiproliferative activity.
    GPX4-IN-8
  • HY-147691
    MPO-IN-5
    		Inhibitor
    MPO-IN-5 (compound 1) is a potent, irreversible MPO (myeloperoxidase) inhibitor. MPO-IN-5 inhibits MPO peroxidation and hERG binding, with IC50 values of 0.22 and 2.8 μM, respectively. MPO-IN-5 shows rapid kinetics of inhibition, with enzyme inactivation rate (kinact/Ki) of 23000 M−1s−1.
    MPO-IN-5
  • HY-P990812
    Anti-Mouse myeloperoxidase/MPO Antibody (6D1)
    		Inhibitor
    Anti-Mouse myeloperoxidase/MPO Antibody (6D1) is a kind of mouse IgG2b kappa in vivo mouse antibody, targeting to MPO. The recommend isotype control of Anti-Mouse myeloperoxidase/MPO Antibody (6D1): Mouse IgG2b kappa, Isotype Control (HY-P99982).
    Anti-Mouse myeloperoxidase/MPO Antibody (6D1)
  • HY-116117
    Salicylcurcumin
    		Inhibitor
    Salicylcurcumin is a synthetic curcumin analogue with antioxidant activity. Salicylcurcumin may affect lipid peroxidation in fish, favoring increased survival, disease resistance, and ultimately growth rate.
    Salicylcurcumin
  • HY-157788
    ZX703
    		Degrader
    ZX703 (compound 5I) is a PROTAC that significantly degrades GPX4 in a dose- and time-dependent manner through the ubiquitin-proteasome and autophagy-lysosome pathways (DC50=0.315 µM). ZX703 induces ferroptosis by inducing Reactive Oxygen Species (ROS) accumulation in cells. ZX703 can be used for cancer research.
    ZX703
  • HY-155075
    NC-R17
    		Inhibitor
    NC-R17 is a PROTAC-class, non-covalent GPX4 degrader based on RSL3, involved in ferroptosis. NC-R17 has antitumor activity and is used for non-covalent GPX4 PROTAC design. NC-R17 consists of a target protein ligand (red part) Demethyl-RSL3 (HY-135832); an E3 ubiquitin ligase ligand (blue part) Lenalidomide (HY-A0003) and a PROTAC linker (black part) (HY-169376). E3 ubiquitin ligase and linker can form Lenalidomide-C13-piperazine-Boc (HY-169377).
    NC-R17
  • HY-N0070R
    Solasonine (Standard)
    		Inhibitor
    Solasonine (Standard) is the analytical standard of Solasonine. This product is intended for research and analytical applications. Solasonine is a ferroptosis inducer which can be isolated from Solanum melongena that has anti-infection, anti-cancer, and neurogenesis promoting properties. Solasonine promotes ferroptosis of HCC cells via destruction of the glutathione redox system induced by inhibiting GPX4, and can be used for cancer research.
    Solasonine (Standard)
  • HY-155851
    Lepadin E
    		Inhibitor
    Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect.
    Lepadin E
  • HY-100218B
    (1R,3S)-RSL3
    		Control
    (1R,3S)-RSL3 is the less active (1R,3S)-enantiomer of RSL3 ((1S,3R)-RSL3). (1R,3S)-RSL3 and RSL3 induce cell death in HT22 wild-type cells with EC50 values of 5.2 µM and 0.004 µM, rspectively.
    (1R,3S)-RSL3
  • HY-170798
    Monoamine Oxidase B inhibitor 6
    Monoamine Oxidase B inhibitor 6 (Compound BT5) is a BBB-penatrable, highly selective, reversible and competitive MAO-B inhibitor, with an IC50 of 0.11 μM. Monoamine Oxidase B inhibitor 6 has antioxidant and neuroprotective effects and can be used in the research of neurodegenerative diseases.
    Monoamine Oxidase B inhibitor 6
  • HY-13679R
    Sodium 2-mercaptoethanesulfonate (Standard)
    Sodium 2-mercaptoethanesulfonate (Standard) is the analytical standard of Sodium 2-mercaptoethanesulfonate. This product is intended for research and analytical applications. Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide.
    Sodium 2-mercaptoethanesulfonate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity